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Posted 7 months ago (01 October 2023)

"[The] () inflammasome is a key inflammasome expressed by microglia [2], and is activated by multiple protein aggregates associated with neurodegenerative disease..."

Posted 10 months ago (13 June 2023)

lipo_fan Thanks for the reference. This article is also relevant Quantifying on HDL with nanoparticle-gated electrokinetic membrane sensor for accurate cardiovascular risk assessment

Posted 10 months ago (13 June 2023)

Lowering interferon without interfering with #CART () Could a toci/emapalumab tango improve outcomes for pts? 💃 #bmtsm #lymsm

Posted 10 months ago (13 June 2023)

RT SikkemaLisa: Today our Human Lung Cell Atlas () paper came out in Nature Medicine ! The includes 2.4M c…

Posted 10 months ago (13 June 2023)

Our deep learning-based model showed improved predictive performance of lymph node metastasis 🔍— suggesting that with further refinement and validation, it could be useful in informing clinical decision making. Read the study, published in nature: (1/2)

Posted 11 months ago (18 May 2023)

Recent paper by Habets et al. says "Annotation was performed with RASTtk on the server followed by a manual curation using BLASTp and HHPred and visualization with Easyfig."

Posted 11 months ago (18 May 2023)

2) Source "Three genes containing non-synonymous protein-coding changes associated with severe disease were also found to have significant effects from differential gene expression SLC22A31, and TKY2"

Posted 11 months ago (18 May 2023)

sm9eb MichaelESmith Wadi Feynan 16 is a PPNA site in Jordan with a large communal structure () within the settlement.

Posted 11 months ago (18 May 2023)

Am reading the new paper by yi_ding_ et al. from bpasaniuc lab. An interesting read on polygenic risk scores & their (non)transferability across populations. Given the hype around PRS and their (!) use for embryo selection this Fig. is terrifying.

Posted 11 months ago (17 May 2023)

Deadly mushroom poison might now have an antidote. The mushroom toxin could not enter cells that lacked a functional version of involved in N-glycosylation - Wow, how that be !!!

Posted 11 months ago (17 May 2023)

🚨 New article 🚨 "There is a growing emphasis worldwide on the use of knowledge mobilization () to improve policies and practices with the latest research evidence", Hamid Golhasany & Blane Harvey #UsingEvidenceBetter

Posted 11 months ago (17 May 2023)

Polarizing pyruvate, lactate and simultaneously for multiplexed #hyperpolarized #MRI experiments or improving the throughput of your #dDNP: our last SciReports paper with Thanh Phong Lê and AndreaCapozzi5 powered by snf_ch and CIBM_ch #NMRChat

Posted 11 months ago (17 May 2023)

#Nature A radio-detected type Ia supernova with helium-rich circumstellar material SN showing helium-rich circumstellar material, infrared emission and, for the first time in a SN Ia to our knowledge, a radio counterpart. cc pcoffeebreak

Posted 11 months ago (17 May 2023)

Did you know that the data from our first #OpenScope project with the AllenInstitute on predictive learning in cortex is available on-line! Now, you can find the () paper describing the dataset and linking to all the data/code at ScientificData:

Posted 11 months ago (17 May 2023)

We offer an individual-level interpretation of polygenic score () transferability across genetic ancestries: accuracy varies individual-to-individual across the genetic-ancestry continuum, even in populations usually labeled as homogeneous. 1/

Posted 11 months ago (17 May 2023)

#42 #bestreads NJoshiBWH et al reported triglycerol monostearate () from the #FDA #GRAS pool, generating gels, harnessing arthritis severity dictated drug release for triamcinolone acetonide (by degradation with MMPs’ increase in synovial fluid)

Posted 11 months ago (17 May 2023)

Inhibiting membrane rupture with antibodies limits tissue injury

Posted 11 months ago (17 May 2023)

New paper from the Maguire lab WCHN_UCL asking if hippocampal subfield volumes are associated with autobiographical memory retrieval ability… The full length of 402 hippocampi were ** segmented to bring you an answer! Find out here:

Posted 11 months ago (17 May 2023)

BreakingNewsFi2 KellyGoodmanPhD Censored4sure zianiniSLO Congressizazzho PhilipRafferty5 Yep, I can see the size of the '' with your line of questioning. Meanwhile, science and medicine just get on with their research.

Posted 11 months ago (17 May 2023)

tcastandrew JunkScience We evolved during the Pleistocene, but human civilisation & permanent agriculture only started about 10,000 years ago when the climate was fairly stable with CO2 levels around and global mean surface temperature was about 1.2C less than now.

Posted 11 months ago (16 May 2023)

Deadly mushroom poison might now have an antidote — with help from

Posted 11 months ago (16 May 2023)

13f) refs. more evidence for Hunter-farmer hypothesis- people with '' traits in small-s…

Posted 11 months ago (16 May 2023)

Starchild737 Fly_Sistah DNA studies alone is sufficient in busting this afrocentrist myth. I fail to understand why you regurgitate these absurd ideas to begin with given that the even the "" people (Nilo-Saharan & Cushites) in that region has no ties to modern AA

Posted 11 months ago (16 May 2023)

Interesting findings from an international collaboration led by Cambridge_Uni indicates that problems with the brain's ability to '' itself of unnecessary connections may underlie a wide range of mental health disorders that begin during adolescence

Posted 11 months ago (15 May 2023)

lisajdubreuil Also, Ozempic is not the only glp-1 drug where 2 year sustained weight loss is see. Liraglutide which is weaker version, showed same in 2011. If you apply your own "" logic, the is towards sustained weightloss with therapy continuation.

Posted 11 months ago (14 May 2023)

I am sure the I am the idiot that is missing the plot, but seems to me the main point of their "" theory was already expressed by kjmbishop and me 8 years ago in a quite visible venue ( ). Information content has nothing to do with "aliveness".

Posted 11 months ago (14 May 2023)

GWAS of impulsive personality traits and drug experimentation, with a nice functional follow-up locus in mice by Sanchez-Roige et al. "Porcupine plot" Is it what we're calling it now 😁AbePalmer ?

Posted 11 months ago (14 May 2023)

Vaccinated individuals with severe obesity (BMI > 40 kg/m2) were 76% more likely to experience hospitalization or death from COVID-19

Posted 11 months ago (14 May 2023)

“These may explain how SARS-CoV-2 effectively replicates in asymptomatic individuals without cuasing respiratory dysfunction, and indicate a risk of enhanced coinfection with other viruses.” 💥 💥💥💥💥💥

Posted 11 months ago (13 May 2023)

First author Jason Luke, MD, and colleagues evaluated if epigenetic therapy plus inhibition and immune checkpoint blockade has clinical benefit. Although the it was well-tolerated, it was not associated with substantial clinical response in patients.

Posted 11 months ago (13 May 2023)

Dr. Mohamed Ahmed has show how host interferon-gamma, interacts with Mycobacterium tuberculosis () (via MmpL10) to enhance respiration, growth, and virulence & worsen TB infection). Read the paper here: UKZN AHRI_News satvi_uct SANTHEafrica

Posted 11 months ago (13 May 2023)

NateWeymouth dr_jon_l Kevin_McKernan Fynnderella1 Kevin denied the basic principle of PCR amplifying segments of DNA, instead making a conceptually wrong claim that PCR should use primers spanning the entire SARS-CoV-2 genome (30 kb). He ignores the efficiency of short primers () around 24 bp.

Posted 11 months ago (12 May 2023)

We mapped the global climate-driven transmission potential of #dengue by Aedes #aegypti () & offer a database & R-package as resources towards the identification of past and recent transmission hotspots.

Posted 11 months ago (12 May 2023)

Nearly 25% of TT faculty have at least 1 parent with a ** and over 50% have at least one parents with a masters or more 💀💀 Are ppl on hiring committees going to start seriously considering how bad this is or ? #FirstGenProblems

Posted 11 months ago (12 May 2023)

In a new #CCRAdvance, investigators from CCR’s Genetics Branch have developed a new mouse model for acute myeloid leukemia with NUP98:: gene fusion that reliably recapitulates the human disease, providing a new tool for studying AML:

Posted 11 months ago (12 May 2023)

Here, HongwuQian and colleagues present the cryo-EM structures 3 of human and its complex with CDP-choline and reveal a hydrophobic 4 chamber to accommodate the acyl tails during the catalytic process.

Posted 11 months ago (12 May 2023)

patwebbjr Here it is. Although very early on they use the word '' regarding the link 🤔

Posted 11 months ago (12 May 2023)

Here's a study which takes two groups of doctors- generalists and specialists () and gives them 8 radiological images with a suggested diagnosis.

Posted 11 months ago (11 May 2023)

Amazing collaboration with Vincenzo Salemme and Paola Defilippi: β-Catenin, can orchestrate an anti-tumor immune response influencing the composition of the TME by preventing PMN-MDSC infiltration. Now it is time to drink🥂🥂

Posted 11 months ago (11 May 2023)

“Three-person in vitro fertilization () — involves moving nuclear genetic material from an egg or single-cell embryo with disease-causing mitochondria to a donor egg or embryo that has had its nuclear genetic material removed.”

Posted 11 months ago (11 May 2023)

In a new Research Highlight, we discuss the results of the ROAR trial, which led to the histology-agnostic accelerated approval of dabrafenib + trametinib in unresectable/metastatic solid tumours with mut:

Posted 11 months ago (11 May 2023)

Obesity is linked to accelerated waning of Covid vaccine protection Accelerated waning of the humoral response to vaccines in obesity. Obesity is associated with an increased risk of severe Coronavirus Disease 2019 () infection & mortality

Posted 11 months ago (11 May 2023)

Language models are cool, so why not use them for designing new antibody variants? BrianHie et al. describe a tour de force using ESM models to mutate antibodies, and test that they work! (1/7)

Posted 11 months ago (11 May 2023)

#Hypertens_res Adv. Online Pub. Associations of genetic polymorphisms with salt sensitivity, blood pressure changes and hypertension... Jia H et al ✅#中国 における # の #遺伝子多型 と #食塩感受性 #血圧変化 #高血圧発症 との関連 by SME.K

Posted 11 months ago (11 May 2023)

incredible separation of recurrence curves in pancreatic cancer with mRNA encoded neoantigen vaccine + at MSKCC. Truly exciting result!

Posted 11 months ago (11 May 2023)

XBC.1.6 () has the L452R mutation from Delta which was thought to increase fusogencity, but really seems like it hasn't taken off. Perhaps the ORF8 truncation has something to do with it too.????? Lots to learn still.

Posted 12 months ago (10 May 2023)

#Nature A reflective, metal-rich atmosphere for GJ from its JWST phase curve a sub-Neptune with a dayside and nightside spectra (average brightness temperatures of 553 ± 9 and 437 ± 19 K, resp.) each show >3σ evidence of absorption features, with H2O

Posted 12 months ago (10 May 2023)

New content online! Antibodies cross-reactive with and dsDNA discovered

Posted 12 months ago (10 May 2023)

Holography was proposed by Denis Gabor in 1948 -“to offer a way around” the resolution-limiting spherical aberration of the transmission electron microscope ()

Posted 12 months ago (10 May 2023)

☠️There’s always another Adverse Event. Risk assessment of retinal vascular occlusion after vaccination. “Coronavirus disease 2019 () vaccines are associated with several ocular manifestations.”

Posted 12 months ago (09 May 2023)

InspirallPE BenKoby1911 ncdave4life SpiruSensei Michellesince66 ChrisBBacon3 C_R_O_M________ Climatehope2 DenisDaly priscian AndreGrossza ScienceBlog3 Data79504085 3GHtweets Anvndarnamn5 PvtMcAuslan EdwardRiffle fischerfischy Willard1951 Veritatem2021 AuroriaEn Michael_D_Crow JusticeTrudeau Mark_A_Lunn judgementalbe1 AristotleMrs Coleski14 wallytoms0 LesserMegadeath WernerReinhard5 S_D_Mannix ammocrypta JimBlack48 glinch72 Jaisans stitchnstab CarrudoDon LiveLifeBK24 TheDisproof Joeyd87745119 Devonian1342 Hji45519156 waxliberty SuperFoxyLoxy JaapTitulaer wjack76995 Rocky35418823 NobaconEgbert balls95652097 NASA How do they "" the ultra-low temperatures in Antarctica? With a NEGATIVE GREENHOUSE EFFECT 😂😂😂 The GHE apparently works in whichever way they want - warming, cooling. It could also have no effect whatsoever, if needed:

Posted 12 months ago (09 May 2023)

Heterozygous and homozygous variants in cause a neurodevelopmental disorder with or without epilepsy

Posted 12 months ago (09 May 2023)

Zollitsch et al. present a methodology for the detection of spin dynamics in van der Waals magnets via photon-magnon coupling with a superconducting resonator, with potential to resolve spin dynamics down to a single monolayer NatureComms

Posted 12 months ago (09 May 2023)