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Deep learning-enabled segmentation of ambiguous bioimages with #MachineLearning #NatureJournal #AI
>60: *End 2021: In high-income countries (most Europe, US, Chile; variable use of masks, lockdowns), most important predictor of life expectancy loss lower vax uptake, especially >60 years *Into 2022-23, life expectancy loss from former lockdowns
Happy to share a collaborative paper with MrinalPatnaik LashoTerra MoritzBinderMD on single cell proteogenomic profiling of mutations in blood.
Reuven J Schore: Outstanding outcomes with two low intensity regimens in children with low-risk B-ALL: a report from COG
Intranasal trimeric sherpabody inhibits SARS-CoV-2 including recent immunoevasive Omicron subvariants. cryo-EM results indicate that engagement with induces an all three RBDs up state of the spike.
Acute liver steatosis translationally controls the epigenetic regulator to promote liver regeneration in a study with male mice #fattyliver #epigenetics NatureComms
5/5 No published research agrees with Nahle eg "The evolution of Earth’s climate on geological timescales is largely driven by variations in the magnitude of total solar irradiance () and changes in the greenhouse gas content of the atmosphere"
The association between the total cholesterol level and tuberculosis () risk has been controversial. A low total cholesterol level was significantly associated with an increased risk of , especially in patients <65 years, those w/out DM or obesity.
🌟Research Highlight| In a🆕 study in TheLancetPsych, CastaldelliMaia et al. from usponline show an increased burden of substance use disorders () in South American countries, regardless of their efforts to monitor and restrict 💊. #drugabuse
Deep learning (DL)-based tools could help w/ early disease detection and improve prognosis. In CommsMedicine, researchers use DL tools to detect Mitral Regurgitation & Aortic Stenosis in ECGs. (1/2)
The fact that we only * just * discovered trilobites have median eyes makes me wonder what kinds of other so-called "" significant discoveries are out there, especially with respect to woefully understudied fossil invertebrate clades. #fossilfriday
Exquisite example of the contribution of Radiopharmaceutical Sciences to the development of Antibody–drug conjugates () with high clinical translational potential! 👇Check the recent work of RSG and his collaboratores on SciReports
Asciminib monotherapy in patients with CML-CP without BCR::ABL1 mutations treated with at least two prior TKIs: 4-year phase 1 safety and efficacy results
In this paper, we presented a One Health genome-centric metagenomics dataset with 2,915 metagenome-assembled genomes () of 107 samples from the human (N = 34), cattle (N = 28), swine (N = 15) and poultry (N = 30) gut microbiomes.
A new story, spearheaded by Federica Mangione is out NatureCellBio! 🎉 Federica observed the association of non-neuronal epidermal cells with the developing mechanosensory bristle. (1/2)
With anthropogenic warming & Arctic amp results suggest imminent transition to seasonal sea-ice in S Lincoln Sea, even if global temp kept below 2 °C threshold compared to pre-industrial (1850–1900)
Structural dynamics in evolution of SARSCoV2 spike glycoprotein: changes in spike dynamics asso with transition from closed to open conformations, to binding,to specific mutations in VOCs.RBD-asso subdomain role in spike opening,
RT ChemistryNews: Molecular simulations of dynamics and interaction with ligands
Uracil is an RNA molecule and this ** support the theory of life starting with RNA
First human enterovirus was discovered in 1962... 7 years after polio vaccine was in use. "Recent studies of Enterovirus () in nonhuman primates (NHPs), which could act as a source of future emerging human viral diseases'
In collaboration with Xuemei Chen's lab, we uncovered an essential role of in enabling plant growth plasticity in response to temperature and light changes -- . Congrats to all authors, and many thanks to our collaborators Xuemei_RNAlab.
A novel rare condition associated with deficiency
" activity declines in ageing muscles of mice and humans, and adeno-associated virus-based delivery of ameliorates muscle weakness in Pcyt2-knockout and old mice, offering a therapy for individuals with a rare disease and muscle ageing."
"Indeed, the HDACi-induced expression of MICA specific to HCC cells enhanced natural killer () cell-mediated cytotoxicity in co-culture, which was further reinforced by treatment with an inhibitor of MICA sheddase."
Novel intranasal vaccine targeting SARS-CoV-2 receptor binding domain to mucosal microfold cells and adjuvanted with agonist Riboxxim™ elicits strong antibody and T-cell responses in mice | Scientific Reports
#Oncology #Bioinformatics #AI: researchers have devised a machine learning framework for subgroup identification in non-small cell lung cancer () from molecular data. The framework could help develop precision treatments for patients with -
📗 New in Nature Neuroscience from NaturePortfolio: "Perivascular cells induce microglial phagocytic states and synaptic engulfment via in mouse models of Alzheimer's disease" with Dylan Garceau & MikeSasner: #jaxresearch
kemetnubiakamp amin_farhudi Irish___Rose "given that a high variance was found in lineages from haplogroup in the sample from Equatorial Guinea, our results are also compatible with an origin of the V88 lineages in Central-West Africa."
SSCLabQuips and I wrote a commentary about with a little bit of background and our point of view.
38. Texas State Tech
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